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Target
Procathepsin L
Ligand
BDBM50121292
Substrate
n/a
Meas. Tech.
ChEMBL_48503 (CHEMBL660652)
Ki
210±n/a nM
Citation
 Chowdhury, SF; Sivaraman, J; Wang, J; Devanathan, G; Lachance, P; Qi, H; Ménard, R; Lefebvre, J; Konishi, Y; Cygler, M; Sulea, T; Purisima, EO Design of noncovalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides. J Med Chem 45:5321-9 (2002) [PubMed]  Article 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM50121292
Synonyms:
2-[2-(2-Biphenyl-4-yl-acetylamino)-3-methylsulfanyl-propionylamino]-5-guanidino-pentanoic acid {2-phenyl-1-[2-phenyl-1-(3-phenyl-propylcarbamoyl)-ethylcarbamoyl]-ethyl}-amide | CHEMBL148943
Type:
Small organic molecule
Emp. Form.:
C51H60N8O5S
Mol. Mass.:
897.138
SMILES:
CSCC(NC(=O)Cc1ccc(cc1)-c1ccccc1)C(=O)N[C@H](CCCNC(N)=N)C(=O)NC(Cc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)NCCCc1ccccc1
Structure:
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