Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50145736
Substrate
n/a
Meas. Tech.
ChEMBL_51105 (CHEMBL666466)
Ki
>10000±n/a nM
Citation
 Molteni, V; Penzotti, J; Wilson, DM; Termin, AP; Mao, L; Crane, CM; Hassman, F; Wang, T; Wong, H; Miller, KJ; Grossman, S; Grootenhuis, PD N-phenylphenylglycines as novel corticotropin releasing factor receptor antagonists. J Med Chem 47:2426-9 (2004) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50145736
Synonyms:
1-(2-Chloro-4-methyl-phenylamino)-1-(2-fluoro-phenyl)-4-pyridin-4-yl-butan-2-one | CHEMBL78883
Type:
Small organic molecule
Emp. Form.:
C22H20ClFN2O
Mol. Mass.:
382.858
SMILES:
Cc1ccc(NC(C(=O)CCc2ccncc2)c2ccccc2F)c(Cl)c1
Structure:
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