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Found 222 with Last Name = 'grootenhuis' and Initial = 'pd'
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118719(7-Amino-3-{[1-(2-amino-3-cyclohexyl-propionyl)-pyr...)
Affinity DataKi:  0.140nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118730(7-Amino-3-(2-{[2-(carboxymethyl-amino)-3-cyclohexy...)
Affinity DataKi:  0.210nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118728(7-Amino-3-({1-[2-(carboxymethyl-amino)-3-cyclohexy...)
Affinity DataKi:  0.290nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118739(7-Amino-3-({1-[2-(carboxymethyl-amino)-3-cyclohexy...)
Affinity DataKi:  0.290nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118732(1-(2-Amino-3-phenyl-propionyl)-pyrrolidine-2-carbo...)
Affinity DataKi:  0.300nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Combichem

Curated by ChEMBL
LigandPNGBDBM29568(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Affinity DataKi:  0.320nMAssay Description:Evaluated for binding affinity against alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118729(7-Amino-3-({1-[2-(carboxymethyl-amino)-3-cyclohexy...)
Affinity DataKi:  0.330nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118731((2-{2-[5-Amino-1-(oxazole-2-carbonyl)-pentylcarbam...)
Affinity DataKi:  0.420nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118735(7-Amino-3-({1-[2-(carboxymethyl-amino)-3-cyclohexy...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Combichem

Curated by ChEMBL
LigandPNGBDBM69602(2,3-dihydro-1,4-benzodioxin-3-ylmethyl-[2-(2,6-dim...)
Affinity DataKi:  0.540nMAssay Description:Evaluated for binding affinity against alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118738(7-Amino-3-({1-[2-(carboxymethyl-amino)-3-cyclohexy...)
Affinity DataKi:  0.820nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118718(CHEMBL343804 | {2-[2-(5-Amino-1-phenethylaminooxal...)
Affinity DataKi:  0.840nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Combichem

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  1nMAssay Description:Evaluated for binding affinity against alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118723(CHEMBL342672 | CYCLOTHEONAMIDE A | N-[14-Benzyl-18...)
Affinity DataKi:  1nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118727(2-((R)-1-((S)-2-(((S)-7-amino-1-isopropoxy-1,2-dio...)
Affinity DataKi:  1.10nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Combichem

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  1.40nMAssay Description:Evaluated for binding affinity against alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118720(7-Amino-3-{[1-(2-amino-3-phenyl-propionyl)-pyrroli...)
Affinity DataKi:  1.40nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM29388(Exanta | Melagatran | US11584714, Compound 999)
Affinity DataKi:  2nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118717((S)-N-((S)-6-amino-1-oxo-1-(thiazol-2-yl)hexan-2-y...)
Affinity DataKi:  2nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118737((2-{2-[5-Amino-1-(thiazole-2-carbonyl)-pentylcarba...)
Affinity DataKi:  2.60nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118721((S)-N-((S)-6-amino-1-oxo-1-(thiazol-2-yl)hexan-2-y...)
Affinity DataKi:  3.5nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Combichem

Curated by ChEMBL
LigandPNGBDBM50472725(CHEMBL90588 | CHIR-2279)
Affinity DataKi:  5nMAssay Description:Evaluated for binding affinity against alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118722(2-Amino-N-{[5-amino-1-(thiazole-2-carbonyl)-pentyl...)
Affinity DataKi:  13nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118725(7-Amino-3-{[1-(3-carboxy-2-phenylmethanesulfonylam...)
Affinity DataKi:  15nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50073316(CHEMBL114715 | INOGATRAN | {(R)-1-Cyclohexylmethyl...)
Affinity DataKi:  15nMAssay Description:The inhibitory activity of the compound was tested against thrombin (IIa)More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50038001((2R,4R)-1-((S)-5-(diaminomethyleneamino)-2-(3-meth...)
Affinity DataKi:  19nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118734(6-Amino-2-[2-(5-{[1-(2-amino-3-phenyl-propionyl)-p...)
Affinity DataKi:  28nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50113209((1E)-N'-(2-chlorophenyl)-N-(3-ethynylphenyl)-2-oxo...)
Affinity DataKi:  35nMAssay Description:Binding affinity against human Corticotropin releasing factor receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50113201((1E)-N-(3-fluorophenyl)-N'-(2-methylphenyl)-2-oxop...)
Affinity DataKi:  43nMAssay Description:Binding affinity against human Corticotropin releasing factor receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50113189((1E)-N'-(2-chlorophenyl)-N-(3-fluorophenyl)-2-oxop...)
Affinity DataKi:  43nMAssay Description:Binding affinity against human Corticotropin releasing factor receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50113184((1E)-N-(3-chlorophenyl)-N'-(2-nitrophenyl)-2-oxopr...)
Affinity DataKi:  51nMAssay Description:Binding affinity against human Corticotropin releasing factor receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50113181((1E)-N-(3-ethynylphenyl)-N'-(2-methylphenyl)-2-oxo...)
Affinity DataKi:  62nMAssay Description:Binding affinity against human Corticotropin releasing factor receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50113188((1E)-N-(3-ethynylphenyl)-2-oxo-N'-[2-(trifluoromet...)
Affinity DataKi:  66nMAssay Description:Binding affinity against human Corticotropin releasing factor receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50113206((1E)-N'-(2-chlorophenyl)-N-(3-methylphenyl)-2-oxop...)
Affinity DataKi:  115nMAssay Description:Binding affinity against human Corticotropin releasing factor receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Combichem

Curated by ChEMBL
LigandPNGBDBM50472726(CHEMBL92380 | CHIR-2283)
Affinity DataKi:  140nMAssay Description:Evaluated for binding affinity against alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118724((S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine...)
Affinity DataKi:  146nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50145742((R)-1-(2,4-Dichloro-phenylamino)-4-pyridin-4-yl-1-...)
Affinity DataKi:  154nMAssay Description:Binding affinity towards human corticotropin releasing factor (h-CRF1) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50113208((1E)-N-(3-fluorophenyl)-2-oxo-N'-[2-(trifluorometh...)
Affinity DataKi:  197nMAssay Description:Binding affinity against human Corticotropin releasing factor receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118716((S)-1-(3,3-diphenyl-propionyl)-pyrrolidine-2-carbo...)
Affinity DataKi:  204nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50145735(1-(2-Bromo-phenyl)-1-(2,4-dichloro-phenylamino)-4-...)
Affinity DataKi:  204nMAssay Description:Binding affinity towards human corticotropin releasing factor (h-CRF1) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50113199((1E)-N-(3-chlorophenyl)-N'-(2-methylphenyl)-2-oxop...)
Affinity DataKi:  216nMAssay Description:Binding affinity against human Corticotropin releasing factor receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50145751((R)-1-(2-Chloro-4-methyl-phenylamino)-4-pyridin-4-...)
Affinity DataKi:  244nMAssay Description:Binding affinity towards human corticotropin releasing factor (h-CRF1) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50113154((1E)-N'-(2-methylphenyl)-2-oxo-N-[3-(trifluorometh...)
Affinity DataKi:  291nMAssay Description:Binding affinity against human Corticotropin releasing factor receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50113190((1E)-N'-(2-chlorophenyl)-2-oxo-N-phenylpropanehydr...)
Affinity DataKi:  299nMAssay Description:Binding affinity against human Corticotropin releasing factor receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Combichem

Curated by ChEMBL
LigandPNGBDBM50472727(CHEMBL92379 | CHIR-2276)
Affinity DataKi:  310nMAssay Description:Evaluated for binding affinity against alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50145754(1-(2,4-Dichloro-phenylamino)-1-(2-ethyl-phenyl)-4-...)
Affinity DataKi:  330nMAssay Description:Binding affinity towards human corticotropin releasing factor (h-CRF1) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50145731(1-(2,4-Dichloro-phenylamino)-1-(2,6-dimethyl-pheny...)
Affinity DataKi:  338nMAssay Description:Binding affinity towards human corticotropin releasing factor (h-CRF1) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50145749(1-(2,4-Dichloro-phenylamino)-4-pyridin-4-yl-1-o-to...)
Affinity DataKi:  370nMAssay Description:Binding affinity towards human corticotropin releasing factor (h-CRF1) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Research And Development

Curated by ChEMBL
LigandPNGBDBM50118715(7-Amino-3-({1-[2-(carboxymethyl-amino)-3-cyclohexy...)
Affinity DataKi:  376nMAssay Description:Inhibitory activity against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50145732(2-(2,4-Dichloro-phenylamino)-1-(3-hydroxy-4-methox...)
Affinity DataKi:  387nMAssay Description:Binding affinity towards human corticotropin releasing factor (h-CRF1) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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