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Target
NAD-dependent protein deacetylase sirtuin-2
Ligand
BDBM50156766
Substrate
n/a
Meas. Tech.
ChEMBL_429720 (CHEMBL904294)
IC50
>1000000±n/a nM
Citation
 Tervo, AJ; Kyrylenko, S; Niskanen, P; Salminen, A; Leppänen, J; Nyrönen, TH; Järvinen, T; Poso, A An in silico approach to discovering novel inhibitors of human sirtuin type 2. J Med Chem 47:6292-8 (2004) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-2
Synonyms:
NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2)
Type:
Hydrolase
Mol. Mass.:
43172.62
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
389
Sequence:
MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ
  
Inhibitor
Name:
BDBM50156766
Synonyms:
4-((4-(4-(3,4-dihydroxybenzylideneamino)benzyl)phenylimino)methyl)benzene-1,2-diol | CHEMBL374739
Type:
Small organic molecule
Emp. Form.:
C27H22N2O4
Mol. Mass.:
438.4746
SMILES:
Oc1ccc(\C=N\c2ccc(Cc3ccc(cc3)\N=C\c3ccc(O)c(O)c3)cc2)cc1O
Structure:
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