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Target
NAD-dependent protein deacetylase sirtuin-2
Ligand
BDBM50156768
Substrate
n/a
Meas. Tech.
ChEMBL_429720 (CHEMBL904294)
IC50
>1000000±n/a nM
Citation
 Tervo, AJ; Kyrylenko, S; Niskanen, P; Salminen, A; Leppänen, J; Nyrönen, TH; Järvinen, T; Poso, A An in silico approach to discovering novel inhibitors of human sirtuin type 2. J Med Chem 47:6292-8 (2004) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-2
Synonyms:
NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2)
Type:
Hydrolase
Mol. Mass.:
43172.62
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
389
Sequence:
MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ
  
Inhibitor
Name:
BDBM50156768
Synonyms:
2-((4-(4-(4-(2-hydroxybenzylideneamino)phenoxy)butoxy)phenylimino)methyl)phenol | CHEMBL222147
Type:
Small organic molecule
Emp. Form.:
C30H28N2O4
Mol. Mass.:
480.5543
SMILES:
Oc1ccccc1\C=N\c1ccc(OCCCCOc2ccc(cc2)\N=C\c2ccccc2O)cc1
Structure:
Search PDB for entries with ligand similarity: