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Target
Prostaglandin F2-alpha receptor
Ligand
BDBM50255169
Substrate
n/a
Meas. Tech.
ChEMBL_515730 (CHEMBL1023732)
IC50
7600±n/a nM
Citation
 O'Connell, M; Zeller, W; Burgeson, J; Mishra, RK; Ramirez, J; Kiselyov, AS; Andrésson, T; Gurney, ME; Singh, J Peri-substituted hexahydro-indolones as novel, potent and selective human EP3 receptor antagonists. Bioorg Med Chem Lett 19:778-82 (2009) [PubMed]  Article 
Target
Name:
Prostaglandin F2-alpha receptor
Synonyms:
PF2R_HUMAN | PGF receptor | PGF2 alpha receptor | PGF2-alpha receptor | PTGFR | Prostaglandin F | Prostanoid FP receptor
Type:
Enzyme
Mol. Mass.:
40072.29
Organism:
Homo sapiens (Human)
Description:
P43088
Residue:
359
Sequence:
MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
  
Inhibitor
Name:
BDBM50255169
Synonyms:
3-(1-(2,4-dichlorobenzyl)-3a-methyl-2-oxo-2,3,3a,4,5,6-hexahydro-1H-indol-7-yl)-N-(2,4,5-trifluorophenylsulfonyl)acrylamide | CHEMBL479439
Type:
Small organic molecule
Emp. Form.:
C25H21Cl2F3N2O4S
Mol. Mass.:
573.411
SMILES:
CC12CC(=O)N(Cc3ccc(Cl)cc3Cl)C1=C(CCC2)\C=C\C(=O)NS(=O)(=O)c1cc(F)c(F)cc1F |c:17|
Structure:
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