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Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50283280
Substrate
n/a
Meas. Tech.
ChEBML_79814
IC50
482±n/a nM
Citation
 Kim, BM; Vacca, JP; Guare, JP; Hanifin, CM; Michelson, SR; Darke, P; Zugay, JA; Emini, EA; Schleif, W; Lin, JH; Chen, IW; Vastag, K; Ostovic, D; Anderson, PS; Huff, JR A new hydroxyethylamine class of HIV-1 protease inhibitors with high antiviral potency and oral bioavailability Bioorg Med Chem Lett 4:2273-2278 (1994)    Article 
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM50283280
Synonyms:
CHEMBL75270 | {(1S,2R)-1-Benzyl-3-[2-tert-butylcarbamoyl-4-(3-hydroxy-benzyl)-piperazin-1-yl]-2-hydroxy-propyl}-carbamic acid (S)-(tetrahydro-furan-3-yl) ester
Type:
Small organic molecule
Emp. Form.:
C31H44N4O6
Mol. Mass.:
568.7043
SMILES:
CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccc(O)c2)CCN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CCOC1
Structure:
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