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Target
Substance-P receptor
Ligand
BDBM50049468
Substrate
n/a
Meas. Tech.
ChEMBL_142887 (CHEMBL747298)
IC50
1±n/a nM
Citation
 Mills, SG; MacCoss, M; Underwood, D; Shah, SK; Finke, PE; Miller, DJ; Budhu, RJ; Cascieri, MA; Sadowski, S; Strader, CD 1,2,3-Trisubstituted cyclohexyl substance P antagonists: significance of the ring nitrogen in piperidine-based NK-1 receptor antagonists Bioorg Med Chem Lett 5:1345-1350 (1995)    Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46254.43
Organism:
Homo sapiens (Human)
Description:
P25103
Residue:
407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
  
Inhibitor
Name:
BDBM50049468
Synonyms:
(2S,3S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-2-phenyl-piperidine | (2S,3S)-3-(3,5-bis(trifluoromethyl)benzyloxy)-2-phenylpiperidine | 3-(3,5-Bis-trifluoromethyl-benzyloxy)-2-phenyl-piperidine | CHEMBL27006 | L-733060
Type:
Small organic molecule
Emp. Form.:
C20H19F6NO
Mol. Mass.:
403.3614
SMILES:
FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(c1)C(F)(F)F |r|
Structure:
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