Reaction Details Report a problem with these data
Target
Neutrophil collagenase
Ligand
BDBM50290669
Substrate
n/a
Meas. Tech.
ChEBML_102109
IC50
15±n/a nM
Citation
Baxter, AD; Bhogal, R; Bird, JB; Buckley, GM; Gregory, DS; Hedger, PC; Manallack, DT; Massil, T; Minton, KJ; Montana, JG; Neidle, S; Owen, DA; Watson, RJ Mercaptoacyl matrix metalloproteinase inhibitors: The effect of substitution at the mercaptoacyl moiety Bioorg Med Chem Lett 7:2765-2770 (1997) Article
More Info.:
Target
Name:
Neutrophil collagenase
Synonyms:
CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL
Type:
Enzyme
Mol. Mass.:
53413.48
Organism:
Homo sapiens (Human)
Description:
P22894
Residue:
467
Sequence:
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
Inhibitor
Name:
BDBM50290669
Synonyms:
(S)-2-[4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-mercapto-butyrylamino]-4-methyl-pentanoic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide | CHEMBL92835
Type:
Small organic molecule
Emp. Form.:
C28H34N4O5S
Mol. Mass.:
538.658
SMILES:
CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)C(S)CCN1C(=O)c2ccccc2C1=O