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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50295369
Substrate
n/a
Meas. Tech.
ChEMBL_578563 (CHEMBL1052405)
IC50
10±n/a nM
Citation
 Wan, ZK; Chenail, E; Xiang, J; Li, HQ; Ipek, M; Bard, J; Svenson, K; Mansour, TS; Xu, X; Tian, X; Suri, V; Hahm, S; Xing, Y; Johnson, CE; Li, X; Qadri, A; Panza, D; Perreault, M; Tobin, JF; Saiah, E Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model. J Med Chem 52:5449-61 (2009) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50295369
Synonyms:
(2R)-4-(4-(4-Fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-ylsulfonyl)benzonitrile | CHEMBL551186
Type:
Small organic molecule
Emp. Form.:
C19H17F4N3O2S
Mol. Mass.:
427.416
SMILES:
C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(cc1)C#N)c1ccc(F)cc1C(F)(F)F |r|
Structure:
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