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Target
Thymidine kinase 2, mitochondrial
Ligand
BDBM50118490
Substrate
n/a
Meas. Tech.
ChEMBL_627487 (CHEMBL1111773)
IC50
1500±n/a nM
Citation
 Van Poecke, S; Negri, A; Gago, F; Van Daele, I; Solaroli, N; Karlsson, A; Balzarini, J; Van Calenbergh, S 3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase. J Med Chem 53:2902-12 (2010) [PubMed]  Article 
Target
Name:
Thymidine kinase 2, mitochondrial
Synonyms:
KITM_HUMAN | TK2 | Thymidine kinase, mitochondrial
Type:
PROTEIN
Mol. Mass.:
31013.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1333885
Residue:
265
Sequence:
MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRKHCP
  
Inhibitor
Name:
BDBM50118490
Synonyms:
1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine | 5-Methyl-1-(4-trityloxy-but-2-enyl)-1H-pyrimidine-2,4-dione | CHEMBL101135
Type:
Small organic molecule
Emp. Form.:
C28H26N2O3
Mol. Mass.:
438.5176
SMILES:
Cc1cn(C\C=C/COC(c2ccccc2)(c2ccccc2)c2ccccc2)c(=O)[nH]c1=O
Structure:
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