Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50329364
Substrate
n/a
Meas. Tech.
ChEMBL_675431 (CHEMBL1273568)
Ki
16±n/a nM
Citation
 McGuinness, BF; Cole, AG; Dong, G; Brescia, MR; Shao, Y; Henderson, I; Rokosz, LL; Stauffer, TM; Mannava, N; Kimble, EF; Hicks, C; White, N; Wines, PG; Quadros, E Discovery of 2-aminoimidazopyridine adenosine A(2A) receptor antagonists. Bioorg Med Chem Lett 20:6845-9 (2010) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
AA2AR_RAT | ADENOSINE A2a | Adenosine A2 receptor | Adenosine A2a receptor (A2a) | Adenosine Receptors A2a (A2a) | Adenosine receptor A2a and A3 | Adenosine receptors A2a | Adora2a | Rat striatal adenosine A2a receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45015.65
Organism:
Rattus norvegicus (rat)
Description:
Rat A2A receptors expressed in CHO cells.
Residue:
410
Sequence:
MGSSVYITVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGVRAKGIIAICWVLSFAIGLTPMLGWNNCSQKDGNSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCSTCRHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRTHVLRRQEPFQAGGSSAWALAAHSTEGEQVSLRLNGHPLGVWANGSATHSGRRPNGYTLGLGGGGSAQGSPRDVELPTQERQEGQEHPGLRGHLVQARVGASSWSSEFAPS
  
Inhibitor
Name:
BDBM50329364
Synonyms:
2-(3-cyanobenzamido)-N,N-diethyl-1-(3-methoxypropyl)-1H-benzo[d]imidazole-6-carboxamide | CHEMBL1269901
Type:
Small organic molecule
Emp. Form.:
C24H27N5O3
Mol. Mass.:
433.5029
SMILES:
CCN(CC)C(=O)c1ccc2nc(NC(=O)c3cccc(c3)C#N)n(CCCOC)c2c1
Structure:
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