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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50333777
Substrate
n/a
Meas. Tech.
ChEMBL_700721 (CHEMBL1645936)
EC50
500±n/a nM
Citation
 Makadia, P; Shah, SR; Pingali, H; Zaware, P; Patel, D; Pola, S; Thube, B; Priyadarshini, P; Suthar, D; Shah, M; Giri, S; Trivedi, C; Jain, M; Patel, P; Bahekar, R Effect of structurally constrained oxime-ether linker on PPAR subtype selectivity: Discovery of a novel and potent series of PPAR-pan agonists. Bioorg Med Chem 19:771-82 (2011) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50333777
Synonyms:
(E)-2-(2-Methyl-4-(1-(((5-methyl-2-phenyloxazol-4-yl)-methoxy)imino)ethyl)phenoxy)acetic acid | CHEMBL1644305
Type:
Small organic molecule
Emp. Form.:
C22H22N2O5
Mol. Mass.:
394.4205
SMILES:
C\C(=N/OCc1nc(oc1C)-c1ccccc1)c1ccc(OCC(O)=O)c(C)c1
Structure:
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