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Target
RAF proto-oncogene serine/threonine-protein kinase
Ligand
BDBM50105598
Substrate
n/a
Meas. Tech.
ChEBML_163037
IC50
7600±n/a nM
Citation
 Smith, RA; Barbosa, J; Blum, CL; Bobko, MA; Caringal, YV; Dally, R; Johnson, JS; Katz, ME; Kennure, N; Kingery-Wood, J; Lee, W; Lowinger, TB; Lyons, J; Marsh, V; Rogers, DH; Swartz, S; Walling, T; Wild, H Discovery of heterocyclic ureas as a new class of raf kinase inhibitors: identification of a second generation lead by a combinatorial chemistry approach. Bioorg Med Chem Lett 11:2775-8 (2001) [PubMed]  Article 
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase
Synonyms:
C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase RAF | Serine/threonine-protein kinase C-Raf | cRaf
Type:
Serine/threonine-protein kinase
Mol. Mass.:
73082.52
Organism:
Homo sapiens (Human)
Description:
P04049
Residue:
648
Sequence:
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
  
Inhibitor
Name:
BDBM50105598
Synonyms:
5-tert-Butyl-3-[3-(1-ethyl-1H-pyrrol-3-yl)-ureido]-thiophene-2-carboxylic acid methyl ester | CHEMBL93264 | methyl 5-tert-butyl-3-(3-(1-ethyl-1H-pyrrol-3-yl)ureido)thiophene-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C17H23N3O3S
Mol. Mass.:
349.448
SMILES:
CCn1ccc(NC(=O)Nc2cc(sc2C(=O)OC)C(C)(C)C)c1
Structure:
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