Reaction Details Report a problem with these data
Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50379331
Substrate
n/a
Meas. Tech.
ChEMBL_811974 (CHEMBL2013344)
IC50
26±n/a nM
Citation
 Mihalic, JT; Kim, YJ; Lizarzaburu, M; Chen, X; Deignan, J; Wanska, M; Yu, M; Fu, J; Chen, X; Zhang, A; Connors, R; Liang, L; Lindstrom, M; Ma, J; Tang, L; Dai, K; Li, L Discovery of a new class of ghrelin receptor antagonists. Bioorg Med Chem Lett 22:2046-51 (2012) [PubMed]  Article 
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50379331
Synonyms:
CHEMBL2011822
Type:
Small organic molecule
Emp. Form.:
C33H38N4O5
Mol. Mass.:
570.6786
SMILES:
COc1ccccc1Oc1ccc2NC(=O)CN([C@H](C(C)C)C(=O)NC3CCN(Cc4ccccc4)CC3)C(=O)c2c1 |r|
Structure:
Search PDB for entries with ligand similarity: