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Target
Transmembrane protease serine 6
Ligand
BDBM50394261
Substrate
n/a
Meas. Tech.
ChEMBL_856936 (CHEMBL2160579)
Ki
24000±n/a nM
Citation
 Dosa, S; Stirnberg, M; Lülsdorff, V; Häußler, D; Maurer, E; Gütschow, M Active site mapping of trypsin, thrombin and matriptase-2 by sulfamoyl benzamidines. Bioorg Med Chem 20:6489-505 (2012) [PubMed]  Article 
Target
Name:
Transmembrane protease serine 6
Synonyms:
Matriptase-2 | TMPRSS6 | TMPS6_HUMAN
Type:
PROTEIN
Mol. Mass.:
90001.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1442547
Residue:
811
Sequence:
MLLLFHSKRMPVAEAPQVAGGQGDGGDGEEAEPEGMFKACEDSKRKARGYLRLVPLFVLLALLVLASAGVLLWYFLGYKAEVMVSQVYSGSLRVLNRHFSQDLTRRESSAFRSETAKAQKMLKELITSTRLGTYYNSSSVYSFGEGPLTCFFWFILQIPEHRRLMLSPEVVQALLVEELLSTVNSSAAVPYRAEYEVDPEGLVILEASVKDIAALNSTLGCYRYSYVGQGQVLRLKGPDHLASSCLWHLQGPKDLMLKLRLEWTLAECRDRLAMYDVAGPLEKRLITSVYGCSRQEPVVEVLASGAIMAVVWKKGLHSYYDPFVLSVQPVVFQACEVNLTLDNRLDSQGVLSTPYFPSYYSPQTHCSWHLTVPSLDYGLALWFDAYALRRQKYDLPCTQGQWTIQNRRLCGLRILQPYAERIPVVATAGITINFTSQISLTGPGVRVHYGLYNQSDPCPGEFLCSVNGLCVPACDGVKDCPNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCDCGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCFQEDSMASTVLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGALREGGPISNALQKVDVQLIPQDLCSEVYRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVISWIQQVVT
  
Inhibitor
Name:
BDBM50394261
Synonyms:
CHEMBL2159364
Type:
Small organic molecule
Emp. Form.:
C19H26N6O3S
Mol. Mass.:
418.512
SMILES:
NC(=[NH2+])c1ccc(CNC(=O)CCCNS(=O)(=O)c2ccc(cc2)C(N)=[NH2+])cc1
Structure:
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