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Target
Sodium- and chloride-dependent GABA transporter 1
Ligand
BDBM50426072
Substrate
n/a
Meas. Tech.
ChEMBL_935189 (CHEMBL2317558)
IC50
55±n/a nM
Citation
 Sindelar, M; Lutz, TA; Petrera, M; Wanner, KT Focused pseudostatic hydrazone libraries screened by mass spectrometry binding assay: optimizing affinities toward¿-aminobutyric acid transporter 1. J Med Chem 56:1323-40 (2013) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent GABA transporter 1
Synonyms:
GABA transporter | GABA transporter 1 | Gabt1 | Gat-1 | Gat1 | SC6A1_MOUSE | Slc6a1
Type:
PROTEIN
Mol. Mass.:
67006.26
Organism:
Mus musculus
Description:
ChEMBL_788602
Residue:
599
Sequence:
MATDNSKVADGQISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPSEDIVRPENGPEQPQAGSSASKEAYI
  
Inhibitor
Name:
BDBM50426072
Synonyms:
CHEMBL1190520
Type:
Small organic molecule
Emp. Form.:
C23H29NO3
Mol. Mass.:
367.4813
SMILES:
OC(=O)[C@@H]1CCCN(CCOCCC(c2ccccc2)c2ccccc2)C1 |r|
Structure:
Search PDB for entries with ligand similarity: