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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50426489
Substrate
n/a
Meas. Tech.
ChEMBL_938074 (CHEMBL2327913)
IC50
10.0±n/a nM
Citation
 Wan, ZK; Chenail, E; Li, HQ; Ipek, M; Xiang, J; Suri, V; Hahm, S; Bard, J; Svenson, K; Xu, X; Tian, X; Wang, M; Li, X; Johnson, CE; Qadri, A; Panza, D; Perreault, M; Mansour, TS; Tobin, JF; Saiah, E Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes. ACS Med Chem Lett 4:118-23 (2013) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | 11beta-HSD1A | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_MOUSE | Hsd11 | Hsd11b1
Type:
Enzyme
Mol. Mass.:
32369.70
Organism:
Mus musculus (mouse)
Description:
P50172
Residue:
292
Sequence:
MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
  
Inhibitor
Name:
BDBM50426489
Synonyms:
CHEMBL2322706
Type:
Small organic molecule
Emp. Form.:
C19H19F7N2O3S2
Mol. Mass.:
520.485
SMILES:
C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@](C)(O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F |r|
Structure:
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