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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50441635
Substrate
n/a
Meas. Tech.
ChEMBL_986855 (CHEMBL2438603)
IC50
11500±n/a nM
Citation
 Li, W; Li, S; Higai, K; Sasaki, T; Asada, Y; Ohshima, S; Koike, K Evaluation of licorice flavonoids as protein tyrosine phosphatase 1B inhibitors. Bioorg Med Chem Lett 23:5836-9 (2013) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50441635
Synonyms:
LICOAGRODIN
Type:
Small organic molecule
Emp. Form.:
C45H44O9
Mol. Mass.:
728.8255
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-c1cc(ccc1-[#8])[C@@]12[#8][C@@]34[#6@@H](-[#8]-c5c3ccc(-[#8])c5-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-c3cc(-[#8])ccc3-[#6@@H]4-[#6@@H]1-[#6](=O)-c1cc(-[#6]\[#6]=[#6](\[#6])-[#6])c(-[#8])cc1-[#8]2 |r|
Structure:
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