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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50441636
Substrate
n/a
Meas. Tech.
ChEMBL_986855 (CHEMBL2438603)
IC50
6000±n/a nM
Citation
 Li, W; Li, S; Higai, K; Sasaki, T; Asada, Y; Ohshima, S; Koike, K Evaluation of licorice flavonoids as protein tyrosine phosphatase 1B inhibitors. Bioorg Med Chem Lett 23:5836-9 (2013) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50441636
Synonyms:
LICOAGRONE
Type:
Small organic molecule
Emp. Form.:
C45H42O10
Mol. Mass.:
742.809
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-c1cc2-[#6](=O)C([#8]-c2cc1-[#8])([#6](=O)-c1ccc(-[#8])c(-[#6]\[#6]=[#6](\[#6])-[#6])c1)c1cc(-[#8])c(-[#8])cc1\[#6]=[#6]-1/[#8]-c2c(ccc(-[#8])c2-[#6]\[#6]=[#6](/[#6])-[#6])-[#6]-1=O
Structure:
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