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Target
C-C chemokine receptor type 2
Ligand
BDBM50089363
Substrate
n/a
Meas. Tech.
ChEMBL_1496330 (CHEMBL3579779)
IC50
2.7±n/a nM
Citation
 Carter, PH; Brown, GD; Cherney, RJ; Batt, DG; Chen, J; Clark, CM; Cvijic, ME; Duncia, JV; Ko, SS; Mandlekar, S; Mo, R; Nelson, DJ; Pang, J; Rose, AV; Santella, JB; Tebben, AJ; Traeger, SC; Xu, S; Zhao, Q; Barrish, JC Discovery of a Potent and Orally Bioavailable Dual Antagonist of CC Chemokine Receptors 2 and 5. ACS Med Chem Lett 6:439-44 (2015) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50089363
Synonyms:
CHEMBL3577944
Type:
Small organic molecule
Emp. Form.:
C25H36ClN5O
Mol. Mass.:
458.039
SMILES:
CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@H](Nc2ncnc3ccc(Cl)cc23)C1=O)N(C)C(C)C |r|
Structure:
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