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Target
Linoleate 9S-lipoxygenase-4
Ligand
BDBM86103
Substrate
n/a
Meas. Tech.
Lipoxygenase Inhibition Assay
pH
8±0
Temperature
298.15±0 K
IC50
3.06e+4± 2e+1 nM
Citation
 Ahmad, I; Fatima, I Butyrylcholinesterase, lipoxygenase inhibiting and antifungal alkaloids from Isatis tinctoria. J Enzyme Inhib Med Chem 23:313-6 (2008) [PubMed]  Article 
Target
Name:
Linoleate 9S-lipoxygenase-4
Synonyms:
LOX1.5 | LOX4 | LOX4_SOYBN | Lipoxygenase
Type:
Protein
Mol. Mass.:
96526.62
Organism:
Glycine max (Soybean) (Glycine hispida)
Description:
P38417
Residue:
853
Sequence:
MFPFGQKGQKIKGTMVVMQKNVLDINSITSVGGIVDQGLGFIGSAVDALTFAATKISIQLISATKADGGKGKIGKSTNLRGKITLPTLGAGEQAYDVNFEWDSDFGIPGAFYIKNFMQNEFYLKSLILEDIPNHGTIHFVCNSWVYNSKNYKTDRIFFANNTYLPSETPAPLLKYREEELKNVRGDGTGERKEWDRIYDYDVYNDLGNPDSGDKYARPVLGGSALPYPRRERTGRGKTRKDPNSEKPSDFVYLPRDEAFGHLKSSDFLAYGIKSVSQDVLPVLTDAFDGNILSLEFDNFAEVHKLYEGGVTLPTNFLSKIAPIPVIKEIFRTDGEQFLKYPPPKVMQVDKSAWMTDEEFARETIAGLNPNVIKIIEEFPLSSKLDTQAYGDHTCIIAKEHLEPNLGGLTVEQAIQNKKLFILDHHDYLIPYLRKINANTTKTYATRTIFFLKDDGTLTPLAIELSKPHPQGEEYGPVSEVYVPASEGVEAYIWLLAKAYVVVNDACYHQIISHWLSTHAIVEPFVIATNRQLSVVHPIYKLLFPHYRDTMNINSLARKALVNADGIIEKTFLWGRYSMEMSAVIYKDWVFTDQALPNDLVKRGVAVKDPSAPHGVRLLIEDYPYASDGLEIWDAIKSWVQEYVSFYYKSDEELQKDPELQAWWKELVEVGHGDLKDKPWWQKMQTREELVEASAILIWIASALHAAVNFGQYPYGGLILNRPTISRRFMPEKGSPEYDALAKNPEKEFLKTITGKKETLIDLTVIEILSRHASDEFYLGQRDGGDYWTSDAGPLEAFKRFGKKLEEIEKKLIEKNKDETLRNRYGPAKMPYTLLYPSSEEGLTFRGIPNSISI
  
Inhibitor
Name:
BDBM86103
Synonyms:
3'-Hydroxyepiglucoisatisin, 3
Type:
Small organic molecule
Emp. Form.:
C21H26N2O13S2
Mol. Mass.:
578.567
SMILES:
OCC1OC(SC(CC(OC(=O)CC2(O)C(=O)Nc3ccccc23)C=C)=NOS(O)(=O)=O)C(O)C(O)C1O |w:26.28|
Structure:
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