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Target
Histamine H3 receptor
Ligand
BDBM108327
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
4.2±0.0 nM
Citation
 Gao, Z; Hall, D; Hartung, R Substituted piperidine spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof US Patent  US8604046 Publication Date 12/10/2013 
Target
Name:
Histamine H3 receptor
Synonyms:
n/a
Type:
Enzyme
Mol. Mass.:
43426.88
Organism:
Macaca mulatta (Rhesus macaque)
Description:
G7N499
Residue:
390
Sequence:
MLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGNTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAGGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAAGAEAGETALGGGGGGGTAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEQCWK
  
Inhibitor
Name:
BDBM108327
Synonyms:
US8604046, 107
Type:
Small organic molecule
Emp. Form.:
C30H43F3N4O2
Mol. Mass.:
548.6832
SMILES:
C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(N2CCC3(CCN(CC4CCOCC4)CC3)C2=O)c(c1)C(F)(F)F |r|
Structure:
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