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Found 5460 with Last Name = 'gao' and Initial = 'z'
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108297(US8604046, 77)
Affinity DataKi:  0.00800nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50117108(4-[3-(2-Furan-2-yl-8-methyl-8H-pyrazolo[4,3-e][1,2...)
Affinity DataKi:  0.0100nMAssay Description:Displacement of [3H]-MRE 3008-F20 from Human Adenosine A3 receptor expressed in HEK-293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108281(US8604046, 61)
Affinity DataKi:  0.0300nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108315(US8604046, 95)
Affinity DataKi:  0.0400nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108294(US8604046, 74)
Affinity DataKi:  0.0400nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50117109(1-(2-Furan-2-yl-8-methyl-8H-pyrazolo[4,3-e][1,2,4]...)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [3H]-MRE 3008-F20 from Human Adenosine A3 receptor expressed in HEK-293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108295(US8604046, 75)
Affinity DataKi:  0.0600nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108284(US8604046, 64)
Affinity DataKi:  0.0600nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108282(US8604046, 62)
Affinity DataKi:  0.0700nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108310(US8604046, 90)
Affinity DataKi:  0.0800nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetP2Y purinoceptor 14(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50512416(CHEMBL4447162)
Affinity DataKi:  0.0800nMAssay Description:Inhibition of human P2Y14RMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Mus musculus)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50118812((2S,3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-iodo-benzylami...)
Affinity DataKi:  0.0870nMAssay Description:Displacement of [125I]N6-(-amino-3-iodobenzyl)adenosine-5'-N-methyl-uronamide from mouse recombinant adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108328(US8604046, 108)
Affinity DataKi:  0.0900nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108316(US8604046, 96)
Affinity DataKi:  0.100nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108283(US8604046, 63)
Affinity DataKi:  0.100nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108305(US8604046, 85)
Affinity DataKi:  0.100nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108303(US8604046, 83)
Affinity DataKi:  0.100nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108296(US8604046, 76)
Affinity DataKi:  0.100nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Mus musculus)
Medical College Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50517301(CHEMBL1877326)
Affinity DataKi:  0.140nMAssay Description:Displacement of [3H]N6-R-phenylisopropyladenosine from mouse A1A adenosine receptor expressed in CHO cell membranes after 60 mins by scintillation pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108304(US8604046, 84)
Affinity DataKi:  0.150nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108317(US8604046, 97)
Affinity DataKi:  0.150nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50109461(1-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,...)
Affinity DataKi:  0.160nMAssay Description:Displacement of [3H]-MRE 3008-F20 from Human Adenosine A3 receptor expressed in HEK-293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Mus musculus)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM21221((2S,3S,4R,5R)-5-(2-chloro-6-{[(3-iodophenyl)methyl...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [125I]N6-(-amino-3-iodobenzyl)adenosine-5'-N-methyl-uronamide from mouse recombinant adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50106541(4-Amino-2-(6-cyclopentylamino-purin-9-yl)-5-hydrox...)
Affinity DataKi:  0.190nMAssay Description:Binding affinity at Mutant (H272E) human adenosine A3 receptor expressed in COS-7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108311(US8604046, 91)
Affinity DataKi:  0.200nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A1(Mus musculus)
Medical College Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50517302(CHEMBL4562258)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]N6-R-phenylisopropyladenosine from mouse A1A adenosine receptor expressed in CHO cell membranes after 60 mins by scintillation pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108293(US8604046, 73)
Affinity DataKi:  0.200nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108292(US8604046, 72)
Affinity DataKi:  0.200nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A1(Mus musculus)
Medical College Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  0.210nMAssay Description:Displacement of [3H]N6-R-phenylisopropyladenosine from mouse A1A adenosine receptor expressed in CHO cell membranes after 60 mins by scintillation pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Mus musculus)
Medical College Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM25400((2R,3R,4S,5R)-2-[6-(cyclopentylamino)-9H-purin-9-y...)
Affinity DataKi:  0.220nMAssay Description:Displacement of [3H]N6-R-phenylisopropyladenosine from mouse A1A adenosine receptor expressed in CHO cell membranes after 60 mins by scintillation pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50108018(7-(3-(4-aminophenyl)propyl)-2-(furan-2-yl)-7H-pyra...)
Affinity DataKi:  0.220nMAssay Description:Binding affinity against WT human adenosine A2A receptor expressed in CHO cells using [3H]- ZM-241385More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108309(US8604046, 89)
Affinity DataKi:  0.240nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50252829((2S,3S,4R,5R)-5-(6-(3-iodobenzylamino)-9H-purin-9-...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50252829((2S,3S,4R,5R)-5-(6-(3-iodobenzylamino)-9H-purin-9-...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [125I]I-AB-MECA from human adenosine A3 receptor expressed in CHO cells after 60 mins by gamma counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50252829((2S,3S,4R,5R)-5-(6-(3-iodobenzylamino)-9H-purin-9-...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [125I]I-AB-MECA from human adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50180206((2S,3S,4R,5R)-5-(2-chloro-6-(methylamino)-9H-purin...)
Affinity DataKi:  0.280nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50561600(CHEMBL4788488)
Affinity DataKi:  0.280nMAssay Description:Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-5'-N-methyluronamide from human adrenergic A3 receptor expressed in CHO cell membranes asses...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50180206((2S,3S,4R,5R)-5-(2-chloro-6-(methylamino)-9H-purin...)
Affinity DataKi:  0.280nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50180206((2S,3S,4R,5R)-5-(2-chloro-6-(methylamino)-9H-purin...)
Affinity DataKi:  0.280nMAssay Description:Binding affinity to human adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50163020((1S,2R,3S,4R,5S)-4-(6-(3-chlorobenzylamino)-2-chlo...)
Affinity DataKi:  0.290nMAssay Description:Inhibition of [125I]-AB-MECA binding to human Adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50163020((1S,2R,3S,4R,5S)-4-(6-(3-chlorobenzylamino)-2-chlo...)
Affinity DataKi:  0.290nMAssay Description:Displacement of [3H]I-AB-MECA from human recombinant adenosine A3 receptor expressed in CHO cells after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50163020((1S,2R,3S,4R,5S)-4-(6-(3-chlorobenzylamino)-2-chlo...)
Affinity DataKi:  0.290nMAssay Description:Displacement of [3H]CGS21680 form human adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50300289((1R,2R,3S,4R,5S)-4-(2-chloro-6-(3-chlorobenzylamin...)
Affinity DataKi:  0.290nMAssay Description:Displacement of [125I]AB-MECA from human recombinant adenosine A3 receptor expressed in CHO cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50163020((1S,2R,3S,4R,5S)-4-(6-(3-chlorobenzylamino)-2-chlo...)
Affinity DataKi:  0.290nMAssay Description:Displacement of radioligand from human adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108299(US8604046, 79)
Affinity DataKi:  0.300nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSigma non-opioid intracellular receptor 1(RAT)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50532486(CHEMBL4564992)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]-pentazocine from rat brain sigma1 receptor by PDSP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50532486(CHEMBL4564992)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]-pentazocine from rat brain sigma1 receptor by PDSP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Rattus norvegicus)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM21221((2S,3S,4R,5R)-5-(2-chloro-6-{[(3-iodophenyl)methyl...)
Affinity DataKi:  0.330nMAssay Description:Inhibition of [125I]-AB-MECA binding to rat Adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Rattus norvegicus)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM21221((2S,3S,4R,5R)-5-(2-chloro-6-{[(3-iodophenyl)methyl...)
Affinity DataKi:  0.330nMAssay Description:Displacement of [125I]I-AB-MECA from rat adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Rattus norvegicus)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM21221((2S,3S,4R,5R)-5-(2-chloro-6-{[(3-iodophenyl)methyl...)
Affinity DataKi:  0.330nMAssay Description:Displacement of radioligand from rat A3 adenosine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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