Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM108281
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
0.03±0.0 nM
Citation
 Gao, Z; Hall, D; Hartung, R Substituted piperidine spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof US Patent  US8604046 Publication Date 12/10/2013 
Target
Name:
Histamine H3 receptor
Synonyms:
n/a
Type:
Enzyme
Mol. Mass.:
43426.88
Organism:
Macaca mulatta (Rhesus macaque)
Description:
G7N499
Residue:
390
Sequence:
MLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGNTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAGGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAAGAEAGETALGGGGGGGTAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEQCWK
  
Inhibitor
Name:
BDBM108281
Synonyms:
US8604046, 61
Type:
Small organic molecule
Emp. Form.:
C28H41FN4O3
Mol. Mass.:
500.6485
SMILES:
CC(C)(C)OC(=O)N1CCC2(CCCN(C2=O)c2ccc(cc2F)N2CC[C@@H](C2)N2CCCC2)CC1 |r|
Structure:
Search PDB for entries with ligand similarity: