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Target
Bromodomain-containing protein 4 [58-164]
Ligand
BDBM528582
Substrate
n/a
Meas. Tech.
Binding Assay
IC50
52.0±n/a nM
Citation
 Pham, SM; Chakravarty, S; Kankanala, J; Chen, J; Nayak, AK; Barde, A Substituted 1,6-dihydropyridinones and 1,2-dihydroisoquinolinones as bet inhibitors US Patent  US11192900 Publication Date 12/7/2021 
Target
Name:
Bromodomain-containing protein 4 [58-164]
Synonyms:
BRD4 | BRD4-1 | BRD4_HUMAN | Bromodomain-containing protein 4 (BD1, aa 58-164) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12525.99
Organism:
Homo sapiens (Human)
Description:
O60885[58-164]
Residue:
104
Sequence:
NQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL
  
Inhibitor
Name:
BDBM528582
Synonyms:
US11192900, Compound 2 | US11192900, Example S-9
Type:
Small organic molecule
Emp. Form.:
C22H17F2N3O3
Mol. Mass.:
409.3855
SMILES:
CNc1cc(cn(C)c1=O)-c1cc(NC(=O)C#C)ccc1Oc1ccc(F)cc1F
Structure:
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