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Target
Glucagon-like peptide 1 receptor
Ligand
BDBM349710
Substrate
n/a
Meas. Tech.
CHO GLP-1R Clone C6-Assay 2
EC50
8.80±n/a nM
Citation
Aspnes, GE; Bagley, SW; Curto, JM; Dowling, MS; Edmonds, D; Flanagan, ME; Futatsugi, K; Griffith, DA; Huard, K; Ingle, G; Jiao, W; Limberakis, C; Mathiowetz, AM; Piotrowski, DW; Ruggeri, RB GLP-1 receptor agonists and uses thereof US Patent US10208019 Publication Date 2/19/2019
More Info.:
Target
Name:
Glucagon-like peptide 1 receptor
Synonyms:
GLP-1 receptor | GLP-1-R | GLP-1R | GLP1R | GLP1R_HUMAN | Glucagon-like peptide 1 receptor | Glucagon-like peptide 1 receptor (GLP-1)
Type:
Enzyme
Mol. Mass.:
53035.78
Organism:
Human
Description:
P43220
Residue:
463
Sequence:
MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
Inhibitor
Name:
BDBM349710
Synonyms:
2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl}piperidin-1-yl)methyl]-3-[(2S)-oxetan-2-ylmethyl]-3H-imidazo[4,5-b]pyridine-5-carboxylic acid | US10208019, Example 6A-01
Type:
Small organic molecule
Emp. Form.:
C30H29FN6O4
Mol. Mass.:
556.5875
SMILES:
OC(=O)c1ccc2nc(CN3CCC(CC3)c3cccc(OCc4ccc(cc4F)C#N)n3)n(C[C@@H]3CCO3)c2n1