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Target
Proteinase-activated receptor 1
Ligand
BDBM50034703
Substrate
n/a
Meas. Tech.
ChEBML_90227
IC50
700±n/a nM
Citation
 Hoekstra, WJ; Maryanoff, BE; Andrade-Gordon, P; Cohen, JH; Costanzo, MJ; Damiano, BP; Haertlein, BJ; Harris, BD; Kauffman, JA; Keane, PM; McComsey, DF; Villani, FJ; Yabut, SC Solid-phase parallel synthesis applied to lead optimization: Discovery of potent analogues of the GPIIb/IIIa antagonist RWJ-50042 Bioorg Med Chem Lett 6:2371-2376 (1996)    Article 
Target
Name:
Proteinase-activated receptor 1
Synonyms:
CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1)
Type:
Protein
Mol. Mass.:
47450.07
Organism:
Homo sapiens (Human)
Description:
P25116
Residue:
425
Sequence:
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
  
Inhibitor
Name:
BDBM50034703
Synonyms:
3-{[1-(3-Piperidin-4-yl-propionyl)-piperidine-3-carbonyl]-amino}-propionic acid | CHEMBL289432
Type:
Small organic molecule
Emp. Form.:
C17H29N3O4
Mol. Mass.:
339.4299
SMILES:
OC(=O)CCNC(=O)C1CCCN(C1)C(=O)CCC1CCNCC1
Structure:
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