Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP3 subtype
Ligand
BDBM50311610
Substrate
n/a
Meas. Tech.
ChEMBL_618650 (CHEMBL1101699)
IC50
2±n/a nM
Citation
Hategan, G; Polozov, AM; Zeller, W; Cao, H; Mishra, RK; Kiselyov, AS; Ramirez, J; Halldorsdottir, G; Andrésson, T; Gurney, ME; Singh, J Heterocyclic 1,7-disubstituted indole sulfonamides are potent and selective human EP3 receptor antagonists. Bioorg Med Chem Lett 19:6797-800 (2009) [PubMed] Article
More Info.:
Target
Name:
Prostaglandin E2 receptor EP3 subtype
Synonyms:
PE2R3_HUMAN | PGE receptor, EP3 subtype | PGE2-R | PTGER3 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP3 subtype | Prostaglandin E2 receptor EP3 subtype (EP3) | Prostaglandin E2 receptor EP3A subtype (EP3A) | Prostaglandin E2 receptor EP3D subtype (EP3D) | Prostanoid EP3 receptor
Type:
Enzyme
Mol. Mass.:
43335.03
Organism:
Homo sapiens (Human)
Description:
P43115
Residue:
390
Sequence:
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER
Inhibitor
Name:
BDBM50311610
Synonyms:
4,5-dichloro-N-(5-(1-(2,4-dichlorobenzyl)-5-fluoro-3-methyl-1H-indol-7-yl)pyridin-2-yl)thiophene-2-sulfonamide | CHEMBL1080619
Type:
Small organic molecule
Emp. Form.:
C25H16Cl4FN3O2S2
Mol. Mass.:
615.354
SMILES:
Cc1cn(Cc2ccc(Cl)cc2Cl)c2c(cc(F)cc12)-c1ccc(NS(=O)(=O)c2cc(Cl)c(Cl)s2)nc1