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Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50344583
Substrate
n/a
Meas. Tech.
ChEMBL_748172 (CHEMBL1781851)
IC50
1700±n/a nM
Citation
 Hebeisen, P; Haap, W; Kuhn, B; Mohr, P; Wessel, HP; Zutter, U; Kirchner, S; Ruf, A; Benz, J; Joseph, C; Alvarez-Sánchez, R; Gubler, M; Schott, B; Benardeau, A; Tozzo, E; Kitas, E Orally active aminopyridines as inhibitors of tetrameric fructose-1,6-bisphosphatase. Bioorg Med Chem Lett 21:3237-42 (2011) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36843.58
Organism:
Homo sapiens (Human)
Description:
Liver FBPase (P09467)
Residue:
338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
  
Inhibitor
Name:
BDBM50344583
Synonyms:
5-(2-methoxyethyl)-4-methyl-N-(4-(trifluoromethyl)pyridin-2-ylcarbamoyl)thiophene-2-sulfonamide | CHEMBL1778560
Type:
Small organic molecule
Emp. Form.:
C15H16F3N3O4S2
Mol. Mass.:
423.43
SMILES:
COCCc1sc(cc1C)S(=O)(=O)NC(=O)Nc1cc(ccn1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: