Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM239888
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Ki
720±n/a nM
Comments
extracted
Citation
 Nolte, B; Schröder, W; Linz, K; Englberger, W; Schick, H; Graubaum, H; Braun, B; Ozegowski, S; Bálint, J; Sonnenschein, H Substituted 4-aminocyclohexane derivatives US Patent  US9403767 Publication Date 8/2/2016 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM239888
Synonyms:
US9403767, 46 | US9403767, 47
Type:
Small organic molecule
Emp. Form.:
C19H32N2
Mol. Mass.:
288.4708
SMILES:
CCCCC1(CCC(CC1)(NC)c1ccccc1)N(C)C |(5.23,-1.97,;3.69,-2.02,;2.87,-.72,;1.33,-.77,;.61,-2.13,;1.94,-2.9,;1.94,-4.44,;.61,-5.21,;-.72,-4.44,;-.72,-2.9,;-.11,-6.57,;-1.65,-6.62,;1.33,-6.57,;2.87,-6.62,;3.6,-7.98,;2.78,-9.29,;1.24,-9.24,;.52,-7.88,;-.11,-.77,;-1.65,-.72,;.7,.54,)|
Structure:
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