Reaction Details Report a problem with these data
Target
Sodium-dependent phosphate transport protein 2A
Ligand
BDBM531919
Substrate
n/a
Meas. Tech.
Biological Assays
IC50
1.90±n/a nM
Citation
 Giese, A; Klar, J; Ehrmann, AH; Willwacher, J; Engel, D; Dieskau, AP; Kahnert, A; Gromov, A; Schmeck, C; Lindner, N; Müller, T; Andreevski, AL; Dreher, J; Collins, K Substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine derivatives and uses thereof US Patent  US11208400 Publication Date 12/28/2021 
Target
Name:
Sodium-dependent phosphate transport protein 2A
Synonyms:
NPT2 | NPT2A_HUMAN | Na(+)-dependent phosphate cotransporter 2A | Na(+)/Pi cotransporter 2A | NaPi-2a | NaPi-3 | SLC17A2 | SLC34A1 | Sodium-dependent phosphate transport protein 2A | Sodium-phosphate transport protein 2A | Sodium/phosphate cotransporter 2A | Solute carrier family 34 member 1
Type:
PROTEIN
Mol. Mass.:
68955.19
Organism:
Homo sapiens
Description:
ChEMBL_116742
Residue:
639
Sequence:
MLSYGERLGSPAVSPLPVRGGHVMRGTAFAYVPSPQVLHRIPGTSAYAFPSLGPVALAEHTCPCGEVLERHEPLPAKLALEEEQKPESRLVPKLRQAGAMLLKVPLMLTFLYLFVCSLDMLSSAFQLAGGKVAGDIFKDNAILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLEVSSAIPIIMGSNIGTSVTNTIVALMQAGDRTDFRRAFAGATVHDCFNWLSVLVLLPLEAATGYLHHITRLVVASFNIHGGRDAPDLLKIITEPFTKLIIQLDESVITSIATGDESLRNHSLIQIWCHPDSLQAPTSMSRAEANSSQTLGNATMEKCNHIFVDTGLPDLAVGLILLAGSLVLLCTCLILLVKMLNSLLKGQVAKVIQKVINTDFPAPFTWVTGYFAMVVGASMTFVVQSSSVFTSAITPLIGLGVISIERAYPLTLGSNIGTTTTAILAALASPREKLSSAFQIALCHFFFNISGILLWYPVPCTRLPIRMAKALGKRTAKYRWFAVLYLLVCFLLLPSLVFGISMAGWQVMVGVGTPFGALLAFVVLINVLQSRSPGHLPKWLQTWDFLPRWMHSLKPLDHLITRATLCCARPEPRSPPLPPRVFLEELPPATPSPRLALPAHHNATRL
  
Inhibitor
Name:
BDBM531919
Synonyms:
4-[5-({6-[5-(difluoromethyl)-3-methyl-1H-pyrazol-1-yl]pyrimidin-4-yl}amino)-1-(2-methoxyethyl)-4-methyl-1H-pyrazol-3-yl]benzonitrile | US11208400, Example 554
Type:
Small organic molecule
Emp. Form.:
C23H22F2N8O
Mol. Mass.:
464.4706
SMILES:
COCCn1nc(c(C)c1Nc1cc(ncn1)-n1nc(C)cc1C(F)F)-c1ccc(cc1)C#N
Structure:
Search PDB for entries with ligand similarity: