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Target
Ubiquitin carboxyl-terminal hydrolase 14
Ligand
BDBM536609
Substrate
n/a
Meas. Tech.
USP14 Inhibition Assay
IC50
550±n/a nM
Citation
 Cullen, M; Hauck, S; Geng, B; Foley, M; Bastos, CM; Munoz, B; Haeberlein, M; Tait, B Proteasome activity enhancing compounds US Patent  US11242361 Publication Date 2/8/2022 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 14
Synonyms:
Deubiquitinating enzyme 14 | TGT | UBP14_HUMAN | USP14 | Ubiquitin thioesterase 14 | Ubiquitin-specific-processing protease 14
Type:
PROTEIN
Mol. Mass.:
56058.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_103728
Residue:
494
Sequence:
MPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGNIKIKNGMTLLMMGSADALPEEPSAKTVFVEDMTEEQLASAMELPCGLTNLGNTCYMNATVQCIRSVPELKDALKRYAGALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQFLHMAFPQFAEKGEQGQYLQQDANECWIQMMRVLQQKLEAIEDDSVKETDSSSASAATPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKENQLQLSCFINQEVKYLFTGLKLRLQEEITKQSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDMYELCTPELQEKMVSFRSKFKDLEDKKVNQQPNTSDKKSSPQKEVKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVKRKQDEWIKFDDDKVSIVTPEDILRLSGGGDWHIAYVLLYGPRRVEIMEEESEQ
  
Inhibitor
Name:
BDBM536609
Synonyms:
US11242361, Compound 301
Type:
Small organic molecule
Emp. Form.:
C23H22F2N4O
Mol. Mass.:
408.4438
SMILES:
Cc1c(C(=O)CN2CCCCC2)c2ncc(cc2n1-c1ccc(cc1)C#N)C(F)F
Structure:
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