Reaction Details Report a problem with these data
Target
Large envelope protein
Ligand
BDBM540732
Substrate
n/a
Meas. Tech.
Test Method of EC50 of Anti HBV
EC50
4.00±n/a nM
Citation
 Liu, X; Ren, Q; Yan, G; Goldmann, S; Zhang, Y Dihydropyrimidine compounds and uses thereof in medicine US Patent  US11261190 Publication Date 3/1/2022 
Target
Name:
Large envelope protein
Synonyms:
HBSAG_HBVD3 | S
Type:
n/a
Mol. Mass.:
42772.52
Organism:
Hepatitis B virus
Description:
P03138
Residue:
389
Sequence:
MGQNLSTSNPLGFFPDHQLDPAFRANTANPDWDFNPNKDTWPDANKVGAGAFGLGFTPPHGGLLGWSPQAQGILQTLPANPPPASTNRQSGRQPTPLSPPLRNTHPQAMQWNSTTFHQTLQDPRVRGLYFPAGGSSSGTVNPVLTTASPLSSIFSRIGDPALNMENITSGFLGPLLVLQAGFFLLTRILTIPQSLDSWWTSLNFLGGTTVCLGQNSQSPTSNHSPTSCPPTCPGYRWMCLRRFIIFLFILLLCLIFLLVLLDYQGMLPVCPLIPGSSTTSTGPCRTCMTTAQGTSMYPSCCCTKPSDGNCTCIPIPSSWAFGKFLWEWASARFSWLSLLVPFVQWFVGLSPTVWLSVIWMMWYWGPSLYSILSPFLPLLPIFFCLWVYI
  
Inhibitor
Name:
BDBM540732
Synonyms:
US11261190, Example 60B
Type:
Small organic molecule
Emp. Form.:
C35H38ClFN6O6S
Mol. Mass.:
725.229
SMILES:
COC[C@@H]1[C@H]2CN(C(=O)N2CCN1CC1=C([C@@H](N=C(N1)c1nccs1)c1ccc(F)cc1Cl)C(=O)OC)c1ccc(cc1)C(C)(C)C(=O)OC |r,c:19,t:16|
Structure:
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