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Target
Histone deacetylase 1
Ligand
BDBM411365
Substrate
n/a
Meas. Tech.
HDAC Enzyme Assay
IC50
<10±n/a nM
Citation
 van Duzer, JH; Mazitschek, R Substituted piperazines as selective HDAC1,2 inhibitors US Patent  US11542242 Publication Date 1/3/2023 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM411365
Synonyms:
US10385031, Compound 071 | US10774056, Compound 071 | US11542242, Compound 071
Type:
Small organic molecule
Emp. Form.:
C21H23N5OS
Mol. Mass.:
393.505
SMILES:
CN1CCN(CC1)c1ccc(cn1)C(=O)Nc1cc(ccc1N)-c1cccs1
Structure:
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