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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM597088
Substrate
n/a
Meas. Tech.
TR-FRET Binding Assay
Ki
<0.200±n/a nM
Citation
 Lee, T; Tarr, JC; Jeon, K; Salovich, JM; Shaw, S; Veerasamy, N; Kim, K; Christov, PP; Olejniczak, ET; Zhao, B; Fesik, SW; Bian, Z Substituted indole Mcl-1 inhibitors US Patent  US11596639 Publication Date 3/7/2023 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM597088
Synonyms:
US11596639, Example 687
Type:
Small organic molecule
Emp. Form.:
C38H38Cl2N10O2
Mol. Mass.:
737.68
SMILES:
C[C@@H]1CN(c2cn(C)c3ccc(nc23)-c2nn[nH]n2)C(=O)c2c(CCCOc3cc(C)c(Cl)c(C)c3)c3ccc(Cl)c(-c4c(C)nn(C)c4C)c3n12 |r,wD:1.0,(-.81,4.69,;-.81,3.15,;.72,3.32,;1.63,2.07,;3.16,2.23,;4.22,1.11,;5.61,1.78,;6.94,1.01,;5.41,3.3,;6.41,4.47,;5.9,5.93,;4.38,6.21,;3.38,5.04,;3.9,3.58,;3.87,7.66,;4.77,8.9,;3.87,10.15,;2.4,9.67,;2.4,8.13,;1,.66,;1.9,-.59,;-.53,.5,;-1.43,-.74,;-.96,-2.21,;.54,-2.54,;1.03,-4,;2.53,-4.33,;3.02,-5.79,;4.54,-6.06,;5.06,-7.51,;6.57,-7.82,;4.07,-8.68,;4.55,-10.15,;2.56,-8.42,;1.59,-9.61,;2.03,-6.97,;-2.9,-.27,;-4.23,-1.04,;-5.57,-.27,;-5.57,1.27,;-6.94,1.98,;-4.23,2.04,;-4.23,3.58,;-5.48,4.49,;-6.94,4.01,;-5,5.95,;-3.46,5.95,;-2.69,7.29,;-2.99,4.49,;-1.52,4.01,;-2.9,1.27,;-1.43,1.75,)|
Structure:
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