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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM312061
Substrate
n/a
Meas. Tech.
IRAK4 Kinase Assay
IC50
4.00±n/a nM
Citation
 Lim, J; Altman, MD; Childers, ML; Gibeau, CR; Ho, GD; Tsui, H Carboxamide inhibitors of IRAK4 activity US Patent  US10155765 Publication Date 12/18/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM312061
Synonyms:
N-{3-Carbamoyl-1-[4-(methylsulfamoyl)phenyl]-1H-pyrazol-4-yl}-5-piperazin-1-ylpyrazolo[1,5-a]pyrimidine-3-carboxamide | US9649308, Example 33
Type:
Small organic molecule
Emp. Form.:
C22H24N10O4S
Mol. Mass.:
524.556
SMILES:
CNS(=O)(=O)c1ccc(cc1)-n1cc(NC(=O)c2cnn3ccc(nc23)N2CCNCC2)c(n1)C(N)=O
Structure:
Search PDB for entries with ligand similarity: