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Target
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779]
Ligand
BDBM164371
Substrate
n/a
Meas. Tech.
PDE10A Inhibition Assay
Temperature
298.15±n/a K
IC50
14±n/a nM
Comments
extracted
Citation
 Püschl, A; Nielsen, J; Kehler, J; Kilburn, JP; Marigo, M; Langgård, M Heteroaromatic phenylimidazole derivatives as PDE10A enzyme inhibitors US Patent  US9669029 Publication Date 6/6/2017 
Target
Name:
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779]
Synonyms:
PDE10A | PDE10_HUMAN | PED10A | Phosphodiesterase 10A (PDE10A)
Type:
n/a
Mol. Mass.:
39060.01
Organism:
Homo sapiens (Human)
Description:
Q9Y233[440-779]
Residue:
340
Sequence:
ICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED
  
Inhibitor
Name:
BDBM164371
Synonyms:
US9669029, 74 (S)-1-{2-[2-(5-Methyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-ethyl]-4-thiophen-2-yl-imidazol-1-yl}-3-morpholin-4-yl-propan-2-ol
Type:
Small organic molecule
Emp. Form.:
C23H30N6O2S
Mol. Mass.:
454.588
SMILES:
CC1=CC=CC2NC(CCc3nc(cn3C[C@@H](O)CN3CCOCC3)-c3cccs3)=NN12 |r,c:3,32,t:1|
Structure:
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