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Target
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779]
Ligand
BDBM164394
Substrate
n/a
Meas. Tech.
PDE10A Inhibition Assay
Temperature
298.15±n/a K
IC50
1.70±n/a nM
Comments
extracted
Citation
 Püschl, A; Nielsen, J; Kehler, J; Kilburn, JP; Marigo, M; Langgård, M Heteroaromatic phenylimidazole derivatives as PDE10A enzyme inhibitors US Patent  US9669029 Publication Date 6/6/2017 
Target
Name:
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779]
Synonyms:
PDE10A | PDE10_HUMAN | PED10A | Phosphodiesterase 10A (PDE10A)
Type:
n/a
Mol. Mass.:
39060.01
Organism:
Homo sapiens (Human)
Description:
Q9Y233[440-779]
Residue:
340
Sequence:
ICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED
  
Inhibitor
Name:
BDBM164394
Synonyms:
US9669029, 97 4-{2-[2-(8-Methoxy-5-methyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-ethyl]-4-thiophen-2-yl-imidazol-1-yl}-butyronitrile
Type:
Small organic molecule
Emp. Form.:
C20H23N7OS
Mol. Mass.:
409.508
SMILES:
COC1=CC=C(C)N2N=C(CCc3nc(cn3CCCC#N)-c3cncs3)NC12 |t:2,4,8|
Structure:
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