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Target
Cathepsin S
Ligand
BDBM315284
Substrate
n/a
Meas. Tech.
Cathepsin Enzyme Inhibition Assay
IC50
195±n/a nM
Citation
 Haap, W; Kuehne, H; Mauser, H Piperidine derivatives US Patent  US10172843 Publication Date 1/8/2019 
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM315284
Synonyms:
5-Chloro-3-methyl-1-{1- [5-methyl-2-(4- trifluoromethyl-phenyl)- 1H-imidazol-4- ylmethyl]-piperidin-4- yl}-1,3-dihydro- benzoimidazol-2-one | US10172843, Example 18
Type:
Small organic molecule
Emp. Form.:
C25H25ClF3N5O
Mol. Mass.:
503.947
SMILES:
Cc1[nH]c(nc1CN1CCC(CC1)n1c2ccc(Cl)cc2n(C)c1=O)-c1ccc(cc1)C(F)(F)F
Structure:
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