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Target
Alpha-1A adrenergic receptor
Ligand
BDBM317591
Substrate
n/a
Meas. Tech.
Binding Assay
IC50
28.0±n/a nM
Citation
 Becker-Pelster, EM; Buchgraber, P; Buchmüller, A; Engel, K; Göller, A; Himmel, H; Kast, R; Keldenich, J; Schmeck, C; Tinel, H; Wunder, F Substituted bipiperidinyl derivatives US Patent  US9624199 Publication Date 4/18/2017 
Target
Name:
Alpha-1A adrenergic receptor
Synonyms:
ADA1A_HUMAN | ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C
Type:
Cell-surface receptors
Mol. Mass.:
51511.67
Organism:
Homo sapiens (Human)
Description:
P35348
Residue:
466
Sequence:
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
  
Inhibitor
Name:
BDBM317591
Synonyms:
[(3R)-3-Methyl-1,4′-bipiperidin-1′-yl][6-(morpholin-4-yl)pyridin-3-yl]methanone | US9624199, 1
Type:
Small organic molecule
Emp. Form.:
C21H32N4O2
Mol. Mass.:
372.5044
SMILES:
C[C@@H]1CCCN(C1)C1CCN(CC1)C(=O)c1ccc(nc1)N1CCOCC1
Structure:
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