Reaction Details Report a problem with these data
Target
Protein M2-1
Ligand
BDBM324709
Substrate
n/a
Meas. Tech.
Viral Cytopathic Effect (CPE) Assay
EC50
1184±n/a nM
Citation
 Wang, L; Gao, L; Huang, M; Guo, L; Liang, C; Zhu, W; Feng, S; Zheng, X; Zhang, W; Wu, G; Wang, B; Yun, H Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection US Patent  US10189838 Publication Date 1/29/2019 
Target
Name:
Protein M2-1
Synonyms:
Envelope-associated 22 kDa protein | M2-1 | M21_HRSVA | Matrix M2-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
22163.59
Organism:
Human respiratory syncytial virus A (strain A2)
Description:
P04545
Residue:
194
Sequence:
MSRRNPCKFEIRGHCLNGKRCHFSHNYFEWPPHALLVRQNFMLNRILKSMDKSIDTLSEISGAAELDRTEEYALGVVGVLESYIGSINNITKQSACVAMSKLLTELNSDDIKKLRDNEELNSPKIRVYNTVISYIESNRKNNKQTIHLLKRLPADVLKKTIKNTLDIHKSITINNPKESTVSDTNDHAKNNDTT
  
Inhibitor
Name:
BDBM324709
Synonyms:
3-{5-Chloro-2-[(2'- oxospiro[cyclopropane-1,3'- pyrrolo[2,3-c]pyridin]-1'(2'H)- yl)methyl]-1H-indol-1-yl}-N- (cyclopropylsulfonyl)propanamide | US10189838, Example 19-1
Type:
Small organic molecule
Emp. Form.:
C24H23ClN4O4S
Mol. Mass.:
498.982
SMILES:
Clc1ccc2n(CCC(=O)NS(=O)(=O)C3CC3)c(CN3C(=O)C4(CC4)c4ccncc34)cc2c1
Structure:
Search PDB for entries with ligand similarity: