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Target
Tyrosine-protein phosphatase non-receptor type 1 [1-298]
Ligand
BDBM14291
Substrate
BDBM13466
Meas. Tech.
Phosphatase Inhibition Assay
IC50
470±n/a nM
Citation
 Sparks, RB; Polam, P; Zhu, W; Crawley, ML; Takvorian, A; McLaughlin, E; Wei, M; Ala, PJ; Gonneville, L; Taylor, N; Li, Y; Wynn, R; Burn, TC; Liu, PC; Combs, AP Benzothiazole benzimidazole (S)-isothiazolidinone derivatives as protein tyrosine phosphatase-1B inhibitors. Bioorg Med Chem Lett 17:736-40 (2007) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1 [1-298]
Synonyms:
PTN1_HUMAN | PTP-1B | PTP1B | PTPN1 | PTPase 1B | Protein-Tyrosine Phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase, non-receptor type 1
Type:
Enzyme
Mol. Mass.:
34670.65
Organism:
Homo sapiens (Human)
Description:
The catalytic domain of PTP 1B (residues 1-298) was expressed and purified from E. coli.
Residue:
298
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED
  
Inhibitor
Name:
BDBM14291
Synonyms:
2-[(1S)-1-(1,3-benzothiazol-2-ylamino)-2-[4-(1,1,3-trioxo-1,2-thiazolidin-5-yl)phenyl]ethyl]-1H-1,3-benzodiazole-5-carbonitrile | IZD deriv. 27
Type:
Small organic molecule
Emp. Form.:
C26H20N6O3S2
Mol. Mass.:
528.605
SMILES:
O=C1CC(c2ccc(C[C@H](Nc3nc4ccccc4s3)c3nc4ccc(cc4[nH]3)C#N)cc2)S(=O)(=O)N1 |r|
Structure:
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Substrate
Name:
BDBM13466
Synonyms:
4-Nitrophenyl phosphate disodium salt hexahydrate | 4-nitrophenyl phosphate (pNPP) | disodium (4-nitrophenyl) phosphate | para-nitrophenyl phosphate (pNPP)
Type:
Small organic molecule
Emp. Form.:
C6H4NO6P
Mol. Mass.:
217.0739
SMILES:
[O-][N+](=O)c1ccc(O[P+]([O-])([O-])[O-])cc1
Structure:
Search PDB for entries with ligand similarity: