Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase JAK2 [808-1132]
Ligand
BDBM349105
Substrate
n/a
Meas. Tech.
JAK2 Inhibition Assay
IC50
<100±n/a nM
Citation
Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK Compounds useful for the treatment of degenerative and inflammatory diseases US Patent US10206907 Publication Date 2/19/2019
More Info.:
Target
Name:
Tyrosine-protein kinase JAK2 [808-1132]
Synonyms:
JAK2 | JAK2 (aa 808-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2 JH1 (808-1132)
Type:
Protein
Mol. Mass.:
39171.39
Organism:
Homo sapiens (Human)
Description:
O60674[808-1132]
Residue:
335
Sequence:
FRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
Inhibitor
Name:
BDBM349105
Synonyms:
Cyclopropanecarboxylic acid (5-{4-[(4-cyanomethyl- phenylamino)-methyl]- phenyl-[1,2,4]triazolo[1,5- a]pyridin-2-yl)-amide | US10206907, Compound 224
Type:
Small organic molecule
Emp. Form.:
C25H22N6O
Mol. Mass.:
422.4818
SMILES:
O=C(Nc1nc2cccc(-c3ccc(CNc4ccc(CC#N)cc4)cc3)n2n1)C1CC1