Target
Tyrosine-protein kinase JAK2 [808-1132]
Ligand
BDBM349139
Substrate
n/a
Meas. Tech.
JAK2 Inhibition Assay
IC50
<100±n/a nM
Citation
 Menet, CJVan Rompaey, LJFletcher, SRBlanc, JJouannigot, NHodges, AJSmits, KK Compounds useful for the treatment of degenerative and inflammatory diseases US Patent  US10206907 Publication Date 2/19/2019 
Target
Name:
Tyrosine-protein kinase JAK2 [808-1132]
Synonyms:
JAK2 | JAK2 (aa 808-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2 JH1 (808-1132)
Type:
Protein
Mol. Mass.:
39171.39
Organism:
Homo sapiens (Human)
Description:
O60674[808-1132]
Residue:
335
Sequence:
FRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM349139
Synonyms:
4-[2-(Cyclopropanecarbonyl- amino)-[1,2,4]triazolo[1,5- a]pyridin-5-yl]-N-(1,1-dioxo- tetrahydrothiophen-3-yl)-N- methyl-benzamide | US10206907, Compound 273
Type:
Small organic molecule
Emp. Form.:
C22H23N5O4S
Mol. Mass.:
453.514
SMILES:
CN(C1CCS(=O)(=O)C1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12
Structure:
Search PDB for entries with ligand similarity: