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Target
Tyrosine-protein kinase JAK3 [781-1124]
Ligand
BDBM348979
Substrate
n/a
Meas. Tech.
JAK3 Inhibition Assay
IC50
<100±n/a nM
Citation
 Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK Compounds useful for the treatment of degenerative and inflammatory diseases US Patent  US10206907 Publication Date 2/19/2019 
Target
Name:
Tyrosine-protein kinase JAK3 [781-1124]
Synonyms:
JAK3 | JAK3 (aa 781-1124) | JAK3_HUMAN | Janus kinase 3 (JAK3) | Tyrosine-protein kinase JAK3 | Tyrosine-protein kinase JAK3 (781-1124) | Tyrosine-protein kinase JAK3 (aa 781-1124)
Type:
n/a
Mol. Mass.:
38772.27
Organism:
Homo sapiens (Human)
Description:
P52333[781-1124]
Residue:
344
Sequence:
ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
  
Inhibitor
Name:
BDBM348979
Synonyms:
4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1,5-a]pyridin-5- yl)-N-(4- (trifluoromethyl)phenethyl) benzamide | US10206907, Compound 97
Type:
Small organic molecule
Emp. Form.:
C26H22F3N5O2
Mol. Mass.:
493.4804
SMILES:
FC(F)(F)c1ccc(CCNC(=O)c2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)cc1
Structure:
Search PDB for entries with ligand similarity: