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Target
Mitogen-activated protein kinase 1
Ligand
BDBM15614
Substrate
ERKtide
Meas. Tech.
Enzyme Inhibition Assay
pH
7.5±n/a
Temperature
303.15±n/a K
Ki
2300±n/a nM
Citation
 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Flipped out: structure-guided design of selective pyrazolylpyrrole ERK inhibitors. J Med Chem 50:1280-7 (2007) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM15614
Synonyms:
N,N-dimethyl-4-(4-phenyl-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide | Pyrrole Carboxamide Analog 1
Type:
Small organic molecule
Emp. Form.:
C16H16N4O
Mol. Mass.:
280.3244
SMILES:
CN(C)C(=O)c1cc(c[nH]1)-c1n[nH]cc1-c1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
ERKtide
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1314.49
Organism:
n/a
Description:
n/a
Residue:
13
Sequence:
ATGPLSPGPFGRR