Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Apelin receptor
Ligand
BDBM360422
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding Assay
EC50
0.095±n/a nM
Citation
Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Heath, JA; Horne, DB; Houze, J; Kaller, MR; Khakoo, AY; Kopecky, DJ; Lai, S; Ma, Z; McGee, LR; Medina, JC; Mihalic, JT; Nishimura, N; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Yang, K; Yeh, W; Debenedetto, MV; Farrell, RP; Hedley, SJ; Judd, TC; Kayser, F Triazole agonists of the APJ receptor US Patent US10221162 Publication Date 3/5/2019 More Info.:
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
Inhibitor
Name:
BDBM360422
Synonyms:
(1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-pyridinyl)-4H-1,2,4-triazol-3- | US10221162, Example 760.0
Type:
Small organic molecule
Emp. Form.:
C28H34N8O6S
Mol. Mass.:
610.685
SMILES:
COC1CN(C1)[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:6.6,7.8,(2.97,2.34,;4.3,3.11,;4.3,4.65,;3.21,5.74,;4.3,6.83,;5.39,5.74,;4.3,8.37,;2.97,9.14,;2.97,10.68,;1.63,8.37,;.86,7.03,;2.4,7.03,;.3,9.14,;-1.04,8.37,;-1.2,6.83,;-2.7,6.51,;-3.47,7.85,;-5.01,7.85,;-5.78,9.18,;-7.32,9.18,;-8.09,7.85,;-7.32,6.51,;-8.09,5.18,;-9.63,5.18,;-5.78,6.51,;-2.44,8.99,;-2.76,10.5,;-1.62,11.53,;-.15,11.05,;1.33,11.45,;-1.94,13.04,;-3.4,13.51,;-4.55,12.48,;-4.23,10.97,;-5.72,10.58,;-6.49,11.91,;5.63,9.14,;6.97,8.37,;8.3,9.14,;8.3,10.68,;9.63,11.45,;6.97,11.45,;5.63,10.68,)|
Structure:
