Reaction Details Report a problem with these data
Target
Metallo-beta-lactamase type 2
Ligand
BDBM360881
Substrate
n/a
Meas. Tech.
BIOLOGICAL ASSAYS
IC50
0.287±n/a nM
Citation
Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Metallo-beta-lactamase inhibitors US Patent US10221163 Publication Date 3/5/2019
More Info.:
Target
Name:
Metallo-beta-lactamase type 2
Synonyms:
B2 metallo-beta-lactamase | BLA-IMP | BLAB_SERMA | Beta-lactamase type II | IMP-1 | Metallo-beta-lactamase type II
Type:
undefined
Mol. Mass.:
27125.88
Organism:
Serratia marcescens
Description:
P52699
Residue:
246
Sequence:
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN
Inhibitor
Name:
BDBM360881
Synonyms:
4-(2-amino-1,3- benzothiazol-4-yl)-N1-{[1- (hydroxymethyl)cyclopropyl] methyl}-3-(1H-tetrazol- 5-yl)benzene-1,2- disulfonamide | US10221163, Example 37 | US10544130, Example 37
Type:
Small organic molecule
Emp. Form.:
C19H20N8O5S3
Mol. Mass.:
536.608
SMILES:
Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NCC1(CO)CC1