Reaction Details Report a problem with these data
Target
Histone deacetylase 2
Ligand
BDBM19415
Substrate
BDBM19411
Meas. Tech.
HDAC Enzyme Activity Assay
pH
8±n/a
Temperature
310.15±n/a K
IC50
100±n/a nM
Citation
Moradei, OM; Mallais, TC; Frechette, S; Paquin, I; Tessier, PE; Leit, SM; Fournel, M; Bonfils, C; Trachy-Bourget, MC; Liu, J; Yan, TP; Lu, AH; Rahil, J; Wang, J; Lefebvre, S; Li, Z; Vaisburg, AF; Besterman, JM Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. J Med Chem 50:5543-6 (2007) [PubMed] Article
More Info.:
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
Inhibitor
Name:
BDBM19415
Synonyms:
N-(2-amino-5-phenylphenyl)-4-{[(3,4-dimethoxyphenyl)amino]methyl}benzamide | benzamide-type inhibitor, 11
Type:
Small organic molecule
Emp. Form.:
C28H27N3O3
Mol. Mass.:
453.5323
SMILES:
COc1ccc(NCc2ccc(cc2)C(=O)Nc2cc(ccc2N)-c2ccccc2)cc1OC